Frederik Helmprobst is a neurobiologist who is interested in the presynaptic ultrastructural architectures and the composition and function of their proteins. He studied biology at the Julius-Maximilians University in Wuerzburg and obtained his Bachelor and Masterdegree in the department of cell and developmental biology, where he studied the structure/function relationship of the variant surface glycoproteins in T. brucei brucei during his Master- and Bachelor thesis. Since October 2013 he is working as a PhD-student in the group of Christian Stigloher.
Research synopsis. Frederik Helmprobst uses emerging tomographic techniques such as electron tomography and array tomography in combination with high-pressure freezing to study the ultrastructure of synapses systematically at high resolution in 3D in a near native state. He studies the ultrastructural architecture of synapses at neuromuscular junctions and in the retina in the zebrafish Danio rerio. He is interested in the network of filaments, which is embedding the synaptic vesicles. Furthermore, with array tomography, a correlative light and electron microscopy technique, he tries to identify and localize the components of this intra-vesicular network.